L. reuteri (1)

L. reuteri produces a broad spectrum antibiotic compound called reuterin. The principle effect of reuterin is to kill off competing strains of bacteria and parasites. While reuterin is classed as an antibiotic the designation is somewhat misleading because it implies that L. reuteri is producing reuterin for the benefit of the host. In reality, it is produced for the benefit of itself; the benefit to the host is a convenient side effect. In other words, L. reuteri is killing off other strains of gut bacteria to plow the field for its own colonization i.e. a bit of slash and burn. While I have reason to believe the antibiotic side effect is beneficial overall, I don’t think it is without consequence if your gut is colonized by pathogens that are susceptible to reuterin.

The situational scenario I see happening is L. reuteri entering the GI tract and then opportunistically producing reuterin to kill off competitors, in response to this, the competing bacteria then release their own set of defensive chemicals, e.g. bacteriocins, endotoxin/lipopolysaccharides/lipoglycans. It is completely plausible that this thermonuclear war can lead to host discomfort with accompanying symptomology.

In my anecdotal experience with taking L. reuteri for a month, 1-2 tablets a day with meals, I had minor symptomology indicative of such a scenario. In the first week I did have one day where my stools were loose as a goose, and I intermittently had cold feet indicative of subclinical “endotoxemia”.

The second week, I had symptoms of some sort of modulatory effect on my thyroid hormone axis, feeling a little anxious and some feelings of agitation reminiscent of the times I supplemented with thyroid hormone but those feelings never overwhelmingly became my modus operandi.

By the end of the second and into the third and fourth week I had somewhat increased mucous production or the feeling of a film in my mouth and throat. I also had wild cravings. Wild cravings which I indulged in.

At the end of the fourth week the thyroid symptoms which were intermittent resolved and the mucous production most likely due to the biofilm L. reuteri establishes interacting with my own mucus production had normalized and the cravings winded down.

All throughout the experience I did notice that my digestion improved and that bloating wasn’t an issue by the 3rd and 4th week although bloating was intermittent the first and second week.

Regarding thyroid hormone, while it is possible for a direct effect on the thyroid hormone axis, in my opinion, the effect is likely indirect and a consequence of modulating the microbiome—as in—reducing the bacterial count of bacterial strains that produce chemical species that have an inhibitory effect on the thyroid hormone axis below a physiologically relevant amount.

I do think that this indirect effect is the most likely the route that L. reuteri sustains the more “youthful” hormonal pattern evidenced in the literature and is more in line with a symbiotic relationship rather than a direct effect.

All of the symptoms I had were minor compared to some of the things reported by others who have taken L. reuteri. I want to emphasize that I also spent the beginning of my life into my twenties on antibiotics and that may be why my symptoms were minor, so it is possible I simply had less harmful strains colonized in my GI tract and thus less overall harmful biomass to reduce. Do I think L. reuteri killed all those harmful strains? Not at all, I think it is more likely it reduced bacterial counts and consequently the harmful chemical species they produce below the physiological amounts required to produce symptomology. I do think those potentially harmful species are there, but now I feel they are probably low enough to avoid negative symptoms and perhaps relevantly high enough to produce a hormetic effect on the immune “system” which I view as ideal.

I do think I have been colonized by L. reuteri as the perceived benefits have continued to persist. The literature alludes to the fact that overtime counts of L. reuteri can fall requiring a “booster” after several months but I’m somewhat skeptical of this and think it probably depends on overall eating habits. Since L. reuteri seems to be found naturally in dairy and meat before we cook it, it superficially appears that that should be enough to maintain populations without “boosters”. We shall see how things develop over the coming months.

Overall, I feel happier and more exploratory and patient and I can eat more of the foods I like when I care to have them. To me that is a quality of life improvement and for some of you it might be worth exploring.

5 Comments L. reuteri (1)

  1. Vanner

    All I can say is thanks for bringing this to my attention. The only time I’d thought about L. Reuteri as being therapeutic was for babies with colic, and the use of BioGaia to help.

    I started using BioGaia as an experiment to help with some bloating I’ve been having. To my disbelief it started working right away reducing my acid reflux and bloat. I was surprised because I’d tried other probiotics supplements and foods in the past which did nothing (I hope) — although I still enjoy the taste of foods such as kefir, kraut, and kombucha.

    BioGaia apparently speeds gastric emptying; which I believe is a key factor in it’s effectiveness.

    I hope it keeps working – it’s only been 2 weeks now.

  2. George Henderson

    An interesting feature of reuterin is that acrolein is one of its states.
    ” Reuterin consists of 3-hydroxypropionaldehyde, its hydrate, its dehydration product (acrolein), and its dimer in dynamic equilibrium.”
    Interesting because it is potentially another piece of evidence of adaptation to the products of heating fats, or at least a benefit of heating fats, to go with the greater ApoA1 response to oxidised LA, if acrolein itself has antibiotic properties.

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